The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 139, 785-790, Copyright © 1974 by The Rockefeller University Press

BRIEF DEFINITIVE REPORTS

INHIBITION OF A T-CELL-DEPENDENT IMMUNE RESPONSE IN VITRO BY THYMOMA CELL IMMUNOGLOBULIN

John W. Stocker 1, John J. Marchalonis 1, and Alan W. Harris 1

1 From The Walter and Eliza Hall Institute of Medical Research, P. O. Royal Melbourne Hospital, Victoria, 3050, Australia

Concentrated medium obtained from cultures of a continuous thymus-derived mouse lymphoma cell line (WEHI-22.1) was found to inhibit a T-cell-dependent (antidonkey red blood cell), but not a T-cell-independent (anti-DNP) immune response in vitro. Passage of such a concentrate through an anti-mouse Ig immunoadsorbent column removed its inhibitory activity. It is suggested that the tumor cell Ig can compete with specific normal T-cell Ig in its collaborative function in immune responses. A similar mechanism may account for anergy associated with some human lymphoid neoplasms.

Submitted on December 4, 1973


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