CLONAL NATURE OF THE IMMUNE RESPONSE TO PHOSPHORYLCHOLINE: I. SPECIFICITY, CLASS, AND IDIOTYPE OF PHOSPHORYLCHOLINE-BINDING RECEPTORS ON LYMPHOID CELLS

doi:10.1084/jem.139.1.58

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CLONAL NATURE OF THE IMMUNE RESPONSE TO PHOSPHORYLCHOLINE : I. SPECIFICITY, CLASS, AND IDIOTYPE OF PHOSPHORYLCHOLINE-BINDING RECEPTORS ON LYMPHOID CELLS

J. Latham Claflin ¹, Rose Lieberman ¹, and Joseph M. Davie ¹

¹ From the Departments of Pathology and Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, and the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20014

The relationship between receptor molecules on antigen-bindinglymphocytes (ABC) and antibody produced by antibody-secretingcells was studied in inbred strains of mice using the immuneresponse to phosphorylcholine (PC) as a model system. Splenicand lymph node lymphocytes of nonimmune mice possess rare lymphocyteswhich bind ¹²⁵I-labeled PC-bovine serum albumin. The frequencyof PC-ABC increases after immunization and is paralleled bya rise in the frequency of PC-specific antibody-producing cells.Both of these responses are thymus independent. The receptorson these ABC display specificity for PC and are exclusivelyof the IgM class. In one of the strains, BALB/c, the receptorspossess the same idiotype and fine degree of specificity forPC and two of its analogues, glycerophosphorylcholine and choline,that are characteristic of a PC-binding myeloma, HOPC 8. Furthermore,the idiotype and class of the receptor in these mice do notchange during the course of the immune response. These dataprovide more direct evidence for the immunelogic relevance ofreceptor-bearing lymphocytes.

Submitted on July 30, 1973

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