The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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The Journal of Experimental Medicine, Vol 138, 839-846, Copyright © 1973 by The Rockefeller University Press

ARTICLE

LYMPHOCYTE ACTIVATION IN SUBACUTE SCLEROSING PANENCEPHALITIS VIRUS AND CYTOMEGALOVIRUS INFECTIONS : IN VITRO STIMULATION IN RESPONSE TO VIRAL-INFECTED CELL LINES



G. B. Thurman 1, A. Ahmed 1, D. M. Strong 1, R. C. Knudsen 1, W. R. Grace 1, and K. W. Sell 1

1 From the Experimental Immunology Division, Clinical Medical Sciences Department, Naval Medical Research Institute, National Naval Medical Center, Bethesda, Maryland 20014

Efforts to stimulate lymphocytes from measles seropositive and two patients with subacute sclerosing panencephalitis (SSPE) with either commercially available measles virus or virus isolated from a known case of SSPE failed to show any significant data using a microculture assay. Similar results were obtained using lymphocytes from two patients with active cytomegalovirus (CMV) infections and CMV seropositive individuals using CMV suspensions.

On the other hand, lymphocytes from the patients with subacute sclerosing panencephalitis exhibited in vitro blastogenesis in culture with SSPE virus-infected HeLa cells. Similarly, lymphocytes from the CMV-infected patients demonstrated blastogenesis when cocultivated with CMV-infected WI-38 cells. This affords a new method for determining the cell-mediated immune capacity of patients with "slow" virus diseases.

 Submitted on June 19, 1973


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