The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 138, 723-733, Copyright © 1973 by The Rockefeller University Press

ARTICLE

TRANSFORMATION OF A HISTOCOMPATIBILITY IMMUNOGEN INTO A TOLEROGEN

Stephen H. Nimelstein 1, Allan R. Hotti 1, and Halsted R. Holman 1

1 From the Division of Immunology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305

H-2 antigens on spleen cell membranes absorb antibody to H-2 antigens and induce both humoral and cellular responses. Liver cell membrane H-2 antigens by contrast also absorb antibody but do not influence cellular response and are tolerogenic for the humoral response. This paper demonstrates that syngeneic liver cells contain a substance which can transform the properties of allogeneic spleen cell membranes into those of allogeneic liver cell membranes, i.e., transform a humoral immunogen into a humoral tolerogen. The process appears to be accompanied by cleavage of an antigen component from the spleen membrane and hence to result in a structural change in the H-2 antigen.

Submitted on May 16, 1973


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