The Journal of Experimental Medicine
Accuri Cytometers
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The Journal of Experimental Medicine, Vol 138, 488-494, Copyright © 1973 by The Rockefeller University Press

BRIEF DEFINITIVE REPORTS

MAINTENANCE OF SKIN XENOGRAFTS OF WIDELY DIVERGENT PHYLOGENETIC ORIGIN ON CONGENITALLY ATHYMIC (NUDE) MICE

Dean D. Manning 1, Norman D. Reed 1, and Charles F. Shaffer 1

1 From the Immunobiology Unit, Department of Microbiology, Montana State University, Bozeman, Montana 59715, and the Department of Biology, Wittenberg University, Springfield, Ohio 45501

Congenitally athymic (nude) mice accepted for their lifetime intact skin grafts from distantly related mammals (cat, human) and birds (chicken). They also failed to immunologically reject skin grafts from reptiles (lizards) and amphibians (tree frog), although the skin in these grafts underwent varying degrees of disorganization. A definitive role for the thymic defect in this failure to reject xenografts was established by showing that thymus implantation into nude mice enabled them to reject such foreign skin.

Submitted on May 25, 1973


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