The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 138, 473-478, Copyright © 1973 by The Rockefeller University Press

BRIEF DEFINITIVE REPORTS

HAPTEN-SPECIFIC STIMULATION OF SECONDARY B CELLS INDEPENDENT OF T CELLS

Norman R. Klinman 1 and Robert A. Doughty 1

1 From the Department of Pathology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19174

Treatment of spleen cell suspensions from immunized mice with anti-theta serum and complement before transfer to nonimmune irradiated recipients reduced the degree of in vitro stimulation by hapten-homologous carrier complexes by 90%, but did not decrease at all the number of isolated precursor cells stimulated by hapten on heterologous carriers. Thus, secondary B cells can be stimulated by low concentrations of multiply substituted hapten-carrier complexes in the apparent complete absence of specific T cells.

Submitted on May 29, 1973


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