The Journal of Experimental Medicine
Keystone Symposia
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The Journal of Experimental Medicine, Vol 138, 356-363, Copyright © 1973 by The Rockefeller University Press

ARTICLE

MUTANTS OF NONPRODUCER CELL LINES TRANSFORMED BY MURINE SARCOMA VIRUSES : I. INDUCTION, ISOLATION, PARTICLE PRODUCTION, AND TUMORIGENICITY



M. Hatanaka 1, R. Klein 1, R. Toni 1, J. Walker 1, and R. Gilden 1

1 From the Flow Laboratories, Inc., Rockville, Maryland 20852

A variety of cell mutants were obtained by a single 5'-bromodeoxyuridine (BrdU) treatment of an nonproducer (NP) cell line transformed by the Kirsten strain of murine sarcoma virus (Ki-MSV). Isolation procedures of these cell

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mutants are described. The cell mutants obtained were classified by tumorigenic potential and shedding of Type C virus particles. The cell mutants were classified into four groups: (A) tumorigenic, without particles; (B) tumorigenic, with Type C particles; (C) nontumorigenic, without particles; and (D) nontumorigenic, with Type C particles. The tumorigenic cell lines showed variability in morphology with both flat and typical transformed appearing cell lines showing equal transplantability.

 Submitted on May 1, 1973


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