The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 137, 1201-1212, Copyright © 1973 by The Rockefeller University Press

ARTICLE

HISTOCOMPATIBILITY-LINKED GENETIC CONTROL OF DISEASE SUSCEPTIBILITY : MURINE LYMPHOCYTIC CHORIOMENINGITIS VIRUS INJECTION



Michael B. A. Oldstone 1, Frank J. Dixon 1, Graham F. Mitchell 1, and Hugh O. McDevitt 1

1 From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037, and the Division of Immunology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305

Acute necrotizing inflammatory disease after intracerebral injection of LCM virus is largely dependent on the host immune response to the virus and is controlled, in part, by a dominant gene which is closely linked to the H-2 locus. The F1 hybrid (H-2q/k) from mating a susceptible SWR/J mouse (H-2q/q) to a resistant C3H/HeJ mouse (H-2k/k) is susceptible to LCM virus disease. When such hybrids (H-2q/k) are backcrossed to susceptible parents (H-2q/q), all F2 offspring (H-2q/q, H-2q/k) are highly susceptible. In contrast, hybrid (H-2q/k) backcross to resistant parents (H-2k/k) results in half of the F2 offspring being susceptible (H-2q/k) while the other half are resistant (H-2k/k). Similarly, in congenic H-2q/q and H-2k/k mice, H-2q/q mice are relatively susceptible to acute LCM disease, whereas H-2k/k are resistant.

Submitted on January 10, 1973


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