IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE: I. MORPHOLOGY, QUANTITATION, TISSUE DISTRIBUTION

doi:10.1084/jem.137.5.1142

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IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE : I. MORPHOLOGY, QUANTITATION, TISSUE DISTRIBUTION

Ralph M. Steinman ¹ and Zanvil A. Cohn ¹

¹ From The Rockefeller University, New York 10021

A novel cell type has been identified in adherent cell populationsprepared from mouse peripheral lymphoid organs (spleen, lymphnode, Peyer's patch). Though present in small numbers (0.1–1.6%of the total nucleated cells) the cells have distinct morphologicalfeatures. The nucleus is large, retractile, contorted in shape,and contains small nucleoli (usually two). The abundant cytoplasmis arranged in processes of varying length and width and containsmany large spherical mitochondria. In the living state, thecells undergo characteristic movements, and unlike macrophages,do not appear to engage in active endocytosis. The term, dendriticcell, is proposed for this novel cell type.

Submitted on January 18, 1973

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