The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 137, 547-552, Copyright © 1973 by The Rockefeller University Press

BRIEF DEFINITIVE REPORTS

STIMULATION OF IGG ANTIBODY RESPONSE IN VITRO BY T CELL-REPLACING FACTOR

A. Schimpl 1 and E. Wecker 1

1 From the Institute of Virology, Würzburg, West Germany

A soluble factor (TRF) produced by mixtures of allogeneic mouse spleen, lymph node, and thymus cells functionally replaces T cells in a primary IgM antibody response to sheep blood cells in vitro. It is now shown that TRF can also reconstitute an IgG antibody response in T cell-deprived spleen cultures derived from preimmunized mice. The optimal time of addition and the amount of TRF required differ between primary and secondary in vitro systems.

Submitted on October 30, 1972


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