The Journal of Experimental Medicine
Symposium on Dendritic Cells
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The Journal of Experimental Medicine, Vol 137, 533-536, Copyright © 1973 by The Rockefeller University Press

BRIEF DEFINITIVE REPORTS

PRODUCTION OF TL ANTIBODY BY MICE IMMUNIZED WITH TL- CELL POPULATIONS : A POSSIBLE ASSAY FOR THYMIC HORMONE



Katsutoshi Komuro 1, Edward A. Boyse 1, and Lloyd J. Old 1

1 From the Division of Immunology, Sloan-Kettering Institute for Cancer Research, New York 10021

TL- mice make TL antibody when immunized with spleen or bone marrow cells from TL+ donors, despite the fact that these cells do not express TL antigen. This has been shown to depend on maturation of TL- precursors, contained in the inoculum, into TL+ cells under influence of the recipient's thymus; the differentiated TL+ cells then evoke production of TL antibody.

Submitted on November 13, 1972


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