The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 137, 239-253, Copyright © 1973 by The Rockefeller University Press

ARTICLE

SYNERGY AMONG LYMPHOID CELLS MEDIATING THE GRAFT-VERSUS-HOST RESPONSE : V. DERIVATION BY MIGRATION IN LETHALLY IRRADIATED RECIPIENTS OF TWO INTERACTING SUBPOPULATIONS OF THYMUS-DERIVED CELLS FROM NORMAL SPLEEN



Robert E. Tigelaar 1 and Richard Asofsky 1

1 From the Laboratory of Microbial Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Spleen cells from normal adult mice were injected into lethally irradiated adult syngeneic recipients. 24 h later, cell suspensions were prepared from the recipients' spleens or peripheral lymph nodes and tested either alone or combined for their capacity to elicit graft-versus-host (GVH) reactions in neonatal F1 recipients, using the Simonsen spleen weight assay.

Either the lymph node-seeking subpopulation or the spleen-seeking subpopulation alone was markedly deficient in its ability to provide a GVH reaction when compared with the normal population from which it was derived. However, an appropriate mixture of the two had a reactivity characteristic of the parent population. Both subpopulations were sensitive to treatment with anti-theta antibody and complement in vitro.

These results provide a convincing demonstration of the functional heterogeneity within the pool of thymus-derived cells present in a single normal lymphoid tissue. They strongly suggest that the normal expression of GVH reactivity of such a tissue involves an interaction among distinct subpopulations of thymus-derived cells.

 Submitted on September 14, 1972


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