The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 137, 140-147, Copyright © 1973 by The Rockefeller University Press

ARTICLE

EPSTEIN-BARR VIRUS : HETEROPHILE RESPONSES IN SQUIRREL MONKEYS INOCULATED WITH VIRUS-TRANSFORMED AUTOLOGOUS LEUKOCYTES



Thomas Shope 1 and George Miller 1

1 From the Departments of Pediatrics, and Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06510

Epstein-Barr virus (EBV)-transformed autologous lymphoblasts were repeatedly inoculated into three squirrel monkeys. Each animal developed the heterophile antibodies of infectious mononucleosis and EBV-specific antibodies. After serologic responses had disappeared or markedly declined, the animals were challenged with either whole cells, cell filtrate, or cell ghosts. Animals challenged with living cells and cell ghosts developed agglutinin responses; the recipient of filtrate did not. The results suggest that EBV induces the appearance of the infectious mononucleosis heterophile antigen on the transformed cell membrane.

Submitted on September 15, 1972


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