The Journal of Experimental Medicine
StemCell Technologies
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The Journal of Experimental Medicine, Vol 136, 1063-1071, Copyright © 1972 by The Rockefeller University Press

ARTICLE

VARIATIONS IN THE RESPONSES OF C57BL/10J AND A/J MICE TO SHEEP RED BLOOD CELLS : I. SEROLOGICAL CHARACTERIZATION AND GENETIC ANALYSIS



Donald M. Silver 1, Ian F. C. McKenzie 1, and Henry J. Winn 1

1 From the Division of Immunology, Harvard Medical School; the Transplant Unit, General Surgical Services, and the Department of Surgery, Harvard Medical School at the Massachusetts General Hospital, Boston, Massachusetts 02114

In response to repeated injections of sheep red blood cells, C57BL/10J mice produce predominantly 19S antibody in increasingly higher amounts, while A/J mice initially produce 19S antibody and then switch to produce increasing 7S antibody titers. In an F1 generation all mice responded like the C57BL/10J mice. Backcross data implied genetic control involving at least three loci.

Submitted on June 6, 1972


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