The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 136, 663-675, Copyright © 1972 by The Rockefeller University Press

ARTICLE

SURFACE ANTIGENS OF IMMUNOCOMPETENT CELLS : III. IN VITRO STUDIES OF THE ROLE OF B AND T CELLS IN IMMUNOLOGICAL MEMORY



J. J. Mond 1, T. Takahashi 1, and G. J. Thorbecke 1

1 From the New York University Medical Center, New York 10016

The effect of preincubation with anti-theta or anti-mouse immunoglobulin (Ig) and complement (C') on immune responsiveness of spleen cells from BALB/c mice immunized with sheep erythrocytes (SE) was investigated. Both treatments greatly depressed the remaining ability to produce a secondary response to SE in vitro.

Normal BALB/c spleen cells were far less effective in reconstituting the responses of such depleted cell populations than were much smaller numbers of untreated immune spleen cells. Thymus-derived cell (T cell) memory appeared early after immunization and showed specificity for the immunizing antigens.

Recombination of anti-Ig-treated with anti-theta-treated immune spleen cells resulted in virtually complete reconstitution of responsiveness. The presence of immunological memory in T cells and the nature of their surface receptors are discussed.

 Submitted on March 28, 1972


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