The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 136, 403-408, Copyright © 1972 by The Rockefeller University Press

BRIEF DEFINITIVE REPORTS

ANTIGEN BINDING AND CAPPING BY LYMPHOCYTES OF GENETIC NONRESPONDER MICE

Edward K. Dunham 1, Emil R. Unanue 1, and Baruj Benacerraf 1

1 From the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Radioautographic study of the binding of GAT-125I to spleen cells of genetic responder and nonresponder mice demonstrates that among mice not injected with antigen all strains have approximately the same number of antigen-binding cells; after injection with antigen the number of antigen-binding cells increases in responders but not in nonresponders. Nonresponders are shown to make antibody after injection with GAT complexed with an immunogenic carrier, demonstrating the presence of potentially functional B cells in responders and nonresponders alike. When incubated in the warm, antigen-binding cells of both responders and nonresponders concentrate antigen at one pole of the cell, forming caps.

Submitted on June 5, 1972


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