The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 136, 375-380, Copyright © 1972 by The Rockefeller University Press

BRIEF DEFINITIVE REPORTS

ANTIBODY-MEDIATED SUPPRESSION OF GRAFTED LYMPHOMA CELLS : II. PARTICIPATION OF MACROPHAGES



Hyun S. Shin 1, Nathan Kaliss 1, David Borenstein 1, and Maurice K. Gately 1

1 From the Department of Microbiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, and The Jackson Laboratory, Bar Harbor, Maine 04609

Specific alloantibody admixed with a grafted murine lymphoma is suppressive of the graft in mice of the inbred strain native to the tumor. Suppressive capacity of the host is obviated in mice given 500 R whole body irradiation before tumor inoculation but is restored when normal peritoneal macrophages are admixed with the tumor-antibody inoculum. Other normal cell types admixed with the tumor-antibody inoculum are not effective in restoring suppressive capacity.

Submitted on April 10, 1972


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