The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 136, 369-374, Copyright © 1972 by The Rockefeller University Press

BRIEF DEFINITIVE REPORTS

BRAIN-ASSOCIATED STEM CELL ANTIGEN: AN ANTIGEN SHARED BY BRAIN AND HEMOPOIETIC STEM CELLS

Edward S. Golub 1

1 From the Department of Biological Sciences, Purdue University, Lafayette, Indiana 47907

There is an antigen on mouse brain tissue which is shared by the hemopoietic colony-forming unit or stem cell of the mouse. Treatment of bone marrow or fetal liver cells with anti-brain antisera inhibits expression of colony-forming units. The anti-stem cell antibody is not absorbed by thymus cells and thus can be distinguished from the anti-thymocyte antibody which these antisera also contain.

Submitted on May 15, 1972


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