Ellen S. Vitetta ¹, Celso Bianco ¹, Victor Nussenzweig ¹, and Jonathan W. Uhr ¹

¹ From the Irvington House Institute and the Departments of Medicine and Pathology, New York University School of Medicine, New York 10016

Thymocytes, bone marrow cells, and their derived T and B cell populations were examined for the presence of Ig by the cell surface radioiodination technique. Both IgM and IgG were identified on bone marrow cells. Thymocytes and T cells had no detectable cell surface Ig. Radiolabeling of mixtures of B cells and thymocytes suggest that the method may detect as little as 250 molecules of Ig per cell. Based on these findings, we suggest that the T cell receptor for antigen is not a conventional tetrameric Ig.

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This article has been cited by other articles:

• Vitetta, E., Uhr, J. (1975). Immunoglobulin-receptors revisited. Science 189: 964-969  
• Sell, S., Sheppard, H. W. Jr. (1973). Rabbit Blood Lymphocytes May Be T Cells with Surface Immunoglobulins. Science 182: 586-587 [Abstract]  
• Hauptfeld, V., Klein, D., Klein, J. (1973). Serological Identification of an Ir-Region Product. Science 181: 167-169 [Abstract]  

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