The Journal of Experimental Medicine
StemCell Technologies
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The Journal of Experimental Medicine, Vol 135, 890-906, Copyright © 1972 by The Rockefeller University Press

ARTICLE

CELLS MEDIATING SPECIFIC IN VITRO CYTOTOXICITY : II. PROBABLE AUTONOMY OF THYMUS-PROCESSED LYMPHOCYTES (T CELLS) FOR THE KILLING OF ALLOGENEIC TARGET CELLS



Pierre Golstein 1, Hans Wigzell 1, Henric Blomgren 1, and Erik A. J. Svedmyr 1

1 From the Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden

In order to investigate whether only T cells are involved in a cell-mediated cytotoxic system in vitro, we tested the cytotoxicity of immune killing cell populations as deprived as possible of B cells. Educated thymus cells, immune spleen cells purified by filtration through a column of beads coated with antimouse Ig antiserum, and finally educated thymus cells further purified by filtration through such a column fully retained their specific cytotoxic activity. This very strongly suggests that only T cells are involved in the killing of target cells by allogeneic immune cells in vitro, in this system.

Receptor-bearing cells involved in killing in the present system are thus very probably T cells. This point was further strengthened by the demonstration of specific adsorption, on the relevant monolayers, of each of the three above mentioned killing cell populations.

 Submitted on November 16, 1971


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