The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 135, 443-457, Copyright © 1972 by The Rockefeller University Press

ARTICLE

VIRAL AND CELLULAR SURFACE ANTIGENS OF MURINE LEUKEMIAS AND MYELOMAS : SEROLOGICAL ANALYSIS BY IMMUNOELECTRON MICROSCOPY



Tadao Aoki 1 and Toshitada Takahashi 1

1 From the Division of Immunology, Sloan-Kettering Institute for Cancer Research, New York 10021

Immunoelectron microscopy (IEM) of mouse cells which were productively infected with murine leukemia virus (MuLV) yielded the following conclusions:

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With two exceptions, the alloantigens H-2, theta, Ly-A, and Ly-B were not present on complete or incomplete virions produced by cells bearing these antigens.The exceptions were H-2k (but not H-2b) and theta both appeared on only a minority of virions and never on more than a small part of the circumference.

The incidental discovery of an additional envelope antigen on virions produced by a BALB/c mouse myeloma but lacking from passage A Gross virions distinguishes these two viruses as MuLV subtypes; it also illustrates that IEM can be applied as a primary tool for antigenic analysis, as well as for its usual purpose of finding out where antigens are situated.

 Submitted on October 12, 1971


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