QUANTITATIVE STUDIES OF NATURALLY OCCURRING MURINE LEUKEMIA VIRUS INFECTION OF AKR MICE

doi:10.1084/jem.135.2.429

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QUANTITATIVE STUDIES OF NATURALLY OCCURRING MURINE LEUKEMIA VIRUS INFECTION OF AKR MICE

Wallace P. Rowe ¹ and Theodore Pincus ¹

¹ From the Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Quantitative studies were made of the organ distribution ofmurine leukemia virus in AKR mice of various ages. Infectiousvirus first appeared shortly before or after birth and was continuouslypresent in all mice thereafter. Highest infectivity titers werefound in uterus and bone, with spleen slightly lower. Virustiters in normal thymus were relatively low, but increased significantlywith the development of thymic lymphoma. The level of viremiadecreased after the 1st month of life, but increased sharplyin lymphomatous mice.

Submitted on October 5, 1971

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