The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 134, 1538-1544, Copyright © 1971 by The Rockefeller University Press

ARTICLE

SPECIFIC IMMUNE RESPONSE GENES OF THE GUINEA PIG : IV. DEMONSTRATION IN RANDOM-BRED GUINEA PIGS THAT RESPONSIVENESS TO A COPOLYMER OF L-GLUTAMIC ACID AND L-TYROSINE IS PREDICATED UPON THE POSSESSION OF A DISTINCT STRAIN 13 HISTOCOMPATIBILITY SPECIFICITY



Harry G. Bluestein M.D.1, Ira Green M.D.1, and Baruj Benacerraf M.D.1

1 From the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, and the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

The lymph node cells from all L-glutamic acid and L-tyrosine (GT) responder random-bred guinea pigs were susceptible to lysis by strain 2 anti-strain 13 isoantisera in the presence of complement. These same antisera were cytolytic for lymph node cells of only some of the GT nonresponder animals. However, after absorption with cells, from a nonresponder guinea pig, susceptible to lysis, the anti-strain 13 antisera were no longer able to lyse cells from any GT nonresponder guinea pigs while retaining a large measure of their cytolytic activity for cells of all GT responder guinea pigs. Thus, at least two major strain 13 histocompatibility specificities are expressed on the cells of random-bred guinea pigs. The genetic locus controlling the expression of only one of those strain 13 histocompatibility specificities is linked to the GT immune response gene.

Submitted on July 28, 1971


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