The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 134, 1335-1348, Copyright © 1971 by The Rockefeller University Press

ARTICLE

H-2-LINKED GENETIC CONTROL OF IMMUNE RESPONSIVENESS TO OVALBUMIN AND OVOMUCOID

Nelson M. Vaz M.D.1, Julia M. Phillips-Quagliata Ph.D.1, Bernard B. Levine M.D.1, and Eda M. Vaz D.D.S.1

1 From the Departments of Medicine and Pathology, New York University School of Medicine, New York 10016

Immune responsiveness of inbred mice to low doses of ovalbumin or ovomucoid is under control of single dominant genes closely linked to alleles of the H-2 locus. High responsiveness to ovomucoid is linked with the H-2a and H-2k alleles, and to ovalbumin with the H-2b, H-2d, and H-2q alleles.

Submitted on July 7, 1971


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