The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 134, 1170-1186, Copyright © 1971 by The Rockefeller University Press

ARTICLE

THE PERITONEAL EXUDATE LYMPHOCYTE : I. DIFFERENCES IN ANTIGEN RESPONSIVENESS BETWEEN PERITONEAL EXUDATE AND LYMPH NODE LYMPHOCYTES FROM IMMUNIZED GUINEA PIGS



David L. Rosenstreich M.D.1, J. Thomas Blake 1, and Alan S. Rosenthal M.D.1

1 From the Laboratory of Clinical Investigation, National Institute of Allergy and, Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Peritoneal exudate lymphocytes from guinea pigs immunized with horse radish peroxidase, dinitrophenyl guinea pig albumin, or ferritin in complete Freund's adjuvant have been shown to be significantly more reactive than other lymphocytes in two in vitro assays of cellular immune function: production of macrophage migration inhibitory factor and antigen-induced lymphocyte proliferation. The enhanced reactivity of peritoneal exudate lymphocytes cannot be accounted for by artifacts introduced by column purification or by the presence of nonlymphoid accessory cells. These observations suggest that the peritoneal exudate lymphocyte pool is a highly enriched source of cellular immune effector cells with specificity directed towards those antigenic determinants to which an animal has been recently exposed.

Submitted on June 23, 1971


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