The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 134, 1083-1094, Copyright © 1971 by The Rockefeller University Press

ARTICLE

CELLULAR RECEPTORS : EFFECT OF ANTI-ALLOANTISERUM ON THE RECOGNITION OF TRANSPLANTATION ANTIGENS



Hansruedy Ramseier Dr. Sc. Techn. Eth1 and Jean Lindenmann M.D.1

1 From the Division of Experimental Microbiology, Institute for Medical Microbiology, University of Zürich, 8006 Zürich, Switzerland

The possibility that a rat alloantiserum DA anti-Lewis possesses similar recognition structures for Lewis transplantation antigens, as do DA immunocompetent cells, was investigated by raising an antiserum against this alloantiserum in (Lewis x DA)F1 hosts. This antiserum, as well as one provoked by injecting DA lymphoid cells, was active against recognition structures for Lewis antigens of DA immunocompetent cells. The anti-(DA anti-Lewis) antiserum displayed the same degree of specificity as was found previously for anti-recognition structure sera prepared by injecting parental strain lymphoid cells into F1 hosts. Since the activities of antisera raised against cell-bound receptors or against the antigen-binding region of an immunoglobulin were indistinguishable, it was concluded that the functional part of cell-associated receptors might be structurally similar to the variable portion of an immunoglobulin.

Submitted on July 6, 1971


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