The Journal of Experimental Medicine
Symposium on Dendritic Cells
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The Journal of Experimental Medicine, Vol 134, 65-71, Copyright © 1971 by The Rockefeller University Press

IMMUNE COMPLEXES IN EXPERIMENTAL ANIMALS

PATHOGENESIS OF IMMUNE COMPLEX GLOMERULONEPHRITIS OF NEW ZEALAND MICE

Frank J. Dixon 1, Michael B. A. Oldstone 1, and Giorgio Tonietti 1

1 From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Observations based on elution of IgG from nephritic kidneys of NZ mice and absorption of the eluted IgG with selected antigens indicate that their immune complex nephritis involves at least two kinds of antigen-antibody complexes. Antibodies reactive with nuclear antigens account for nearly half of the IgG eluted from the kidneys while antibodies reactive with Gross viral antigens make up a significant but lesser amount. Superimposed chronic viral infections affect the nephritis of NZ mice in different ways. LCM and polyoma infections hasten and intensify the antinuclear antibody responses and glomerulonephritis of these mice while LDV infection appears to protect against both antinuclear antibody formation and development of nephritis.


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