The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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The Journal of Experimental Medicine, Vol 134, 201-223, Copyright © 1971 by The Rockefeller University Press

ARTICLE

CARRIER FUNCTION IN ANTI-HAPTEN ANTIBODY RESPONSES : IV. EXPERIMENTAL CONDITIONS FOR THE INDUCTION OF HAPTEN-SPECIFIC TOLERANCE OR FOR THE STIMULATION OF ANTI-HAPTEN ANAMNESTIC RESPONSES BY "NONIMMUNOGENIC" HAPTEN-POLYPEPTIDE CONJUGATES



David H. Katz M.D.1, Joseph M. Davie M.D.1, William E. Paul M.D.1, and Baruj Benacerraf M.D.1

1 From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, and the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Administration of nonimmunogenic 2,4-dinitrophenyl (DNP) conjugates of copolymers of D or L-glutamic acid and lysine (GL) induces hapten-specific tolerance in nonimmune and DNP-ovalbumin-primed strain 13 guinea pigs. This tolerant state is evidenced by depressed anti-DNP antibody synthesis in response to challenge with DNP-ovalbumin and by a diminished frequency of DNP-specific antigen-binding cells and of anti-DNP antibody-secreting cells.

Such a nonimmunogenic compound (DNP-D-GL) will nevertheless elicit a DNP-specific anamnestic antibody response when administered at an appropriate time to DNP-ovalbumin-primed guinea pigs undergoing a graft-versus-host reaction. These experiments are discussed in terms of a two-cell theory of stimulation of antibody responses.

 Submitted on April 13, 1971


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