PEYER'S PATCHES: AN ENRICHED SOURCE OF PRECURSORS FOR IGA-PRODUCING IMMUNOCYTES IN THE RABBIT

doi:10.1084/jem.134.1.188

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ARTICLE

PEYER'S PATCHES: AN ENRICHED SOURCE OF PRECURSORS FOR IGA-PRODUCING IMMUNOCYTES IN THE RABBIT

Susan W. Craig ¹ and John J. Cebra Ph.D.¹

¹ From the Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218

The proliferative and differentiative potential of Peyer'spatch, peripheral blood, and popliteal lymph node cells wasassessed by allogeneic cell transfer followed by quantitationof donor immunocytes by immunofluorescence. It was found thatPeyer's patches are a highly enriched source of cells whichhave the potential to proliferate and differentiate into IgA-producingimmunocytes and that the Peyer's patch cells are far more efficientin seeding the gut of irradiated recipient rabbits with donorcells that give rise to immunoglobulin-producing cells thancells from peripheral blood or popliteal lymph nodes.

Submitted on April 4, 1971

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