A MAJOR GENETIC LOCUS AFFECTING RESISTANCE TO INFECTION WITH MURINE LEUKEMIA VIRUSES: II. APPARENT IDENTITY TO A MAJOR LOCUS DESCRIBED FOR RESISTANCE TO FRIEND MURINE LEUKEMIA VIRUS

doi:10.1084/jem.133.6.1234

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A MAJOR GENETIC LOCUS AFFECTING RESISTANCE TO INFECTION WITH MURINE LEUKEMIA VIRUSES : II. APPARENT IDENTITY TO A MAJOR LOCUS DESCRIBED FOR RESISTANCE TO FRIEND MURINE LEUKEMIA VIRUS

Theodore Pincus M.D.¹, Wallace P. Rowe M.D.¹, and Frank Lilly Ph.D.¹

¹ From the Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, and the Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461

The N-B locus affecting tissue culture infectivity with naturallyoccurring murine leukemia viruses appears to be identical tothe Fv-1 locus described for sensitivity to Friend leukemiavirus. Results of tissue culture studies were parallel to resultsof studies in vivo and indicate that the F-S virus is N-tropicand the F-B virus is NB-tropic. Inbred and partially congenicmouse strains sensitive at Fv-1 show N-type sensitivity; strainsresistant at Fv-1 show B-type sensitivity. The Fv-2 locus doesnot appear to exert significant effect in tissue culture. Knowledgeof N-B type has been useful in predicting Fv-1 sensitivity.

Submitted on January 21, 1971

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