A MAJOR GENETIC LOCUS AFFECTING RESISTANCE TO INFECTION WITH MURINE LEUKEMIA VIRUSES: I. TISSUE CULTURE STUDIES OF NATURALLY OCCURRING VIRUSES

doi:10.1084/jem.133.6.1219

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A MAJOR GENETIC LOCUS AFFECTING RESISTANCE TO INFECTION WITH MURINE LEUKEMIA VIRUSES : I. TISSUE CULTURE STUDIES OF NATURALLY OCCURRING VIRUSES

Theodore Pincus M.D.¹, Janet W. Hartley Ph.D.¹, and Wallace P. Rowe M.D.¹

¹ From the Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Previous studies have indicated that all naturally occurringmurine leukemia viruses propagate significantly more efficientlyon embryo cells of either NIH Swiss or BALB/c mice.

Studiesof the plaquing efficiency of representative viruses on embryocells of various inbred and hybrid mice indicate that the patternof sensitivity of the cells is genetically determined. All of23 strains tested were found to resemble either NIH Swiss (N-type)or BALB/c (B-type) with respect to plaquing efficiency of theseviruses. Virus growth on embryo cells derived from (N-type xB-type)F₁ hybrids indicated dominance of resistance to bothtypes of viruses. Backcross hybrid studies indicated that asingle locus is the primary determinant of the host-range patternsobserved. This locus has no effect on growth of certain laboratory-passagedleukemia viruses which propagate equally well on embryo cellsof all mouse strains, F₁, and backcross hybrids. Though othergenetic and nongenetic factors influence viral growth or expressionin vitro and in vivo, the genetic locus described appears ofmajor significance in the biology of murine leukemia.

Submitted on January 21, 1971

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