MECHANISMS OF RECOVERY FROM A GENERALIZED VIRAL INFECTION: MOUSEPOX: II. PASSIVE TRANSFER OF RECOVERY MECHANISMS WITH IMMUNE LYMPHOID CELLS

doi:10.1084/jem.133.5.1074

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ARTICLE

MECHANISMS OF RECOVERY FROM A GENERALIZED VIRAL INFECTION: MOUSEPOX : II. PASSIVE TRANSFER OF RECOVERY MECHANISMS WITH IMMUNE LYMPHOID CELLS

R. V. Blanden ¹

¹ From the Department of Microbiology, The John Curtin School of Medical Research, The Australian National University, Canberra, A.C.T., Australia

The following passive transfer experiments evaluated the contributionsof the various host responses in recovery from mousepox. (a)Immune spleen cells transferred highly efficient antiviral activity,but preinfected recipients of these cells made no detectablesplenic interferon or antibody in the 24 hr interval after celltransfer. (b) Passively administered interferon was ineffective.(c) Recipients of hyperimmune serum had much more antibody thanrecipients of immune spleen cells but significantly less antiviralactivity. (d) Immune spleen cell populations with antiviralactivity contained mediators of CMI to virus antigens. (e) Theantiviral activity of immune spleen cells was specific; it wasinhibited by in vitro treatment with ATS, anti-light chain serum,and anti-theta ascitic fluid, but not by removal of mononuclearphagocytes from the immune population.

These results are interpretedto mean that recovery mechanisms conferred by immune spleencells were triggered by specifically sensitized, thymus-derivedlymphocytes, and that antibody and interferon responses wereof less importance. A radiosensitive recipient component wasnecessary for the full expression of the antiviral activityof both immune cells and immune serum. It seemed likely thatthis component was the blood monocyte.

Submitted on January 17, 1971

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