¹ From the Institute of Immunology and Rheumatology, Rikshospitalet University Hospital, Oslo, Norway, and The Rockefeller University, New York 10021

A survey of a large number of human sera with the heavy chain genetic markers of the -globulin system has revealed an unusual gene complex which is inherited as a unit through two different families. The gene complex involves two pairs of G1 genetic markers which ordinarily behave as homoalleles, Gm^z and Gm^f for the Fd part of G1 molecules, and Gm^a and non-a for the Fc part. Isolation of the G1 fraction from the unusual sera demonstrated the presence of the important non-a antigen in the G1 fraction. Through the use of immunoadsorbents it was shown that these antigens were not part of a single molecule but that separate molecules were involved. The accumulated evidence indicated that the appearance of such homoalleles on the same chromosome probably resulted from a recent gene duplication, giving rise to two G1 cistrons on one chromosome.

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