The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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The Journal of Experimental Medicine, Vol 133, 260-274, Copyright © 1971 by The Rockefeller University Press

ARTICLE

HISTOCOMPATIBILITY STUDIES IN A CLOSELY BRED COLONY OF DOGS : II. INFLUENCE OF THE DL-A SYSTEM OF CANINE HISTOCOMPATIBILITY UPON THE SURVIVAL OF CARDIAC ALLOGRAFTS



Felix T. Rapaport M.D.1, Arthur D. Boyd M.D.1, Frank C. Spencer M.D.1, Richard R. Lower M.D.1, Jean Dausset M.D.1, Florence D. Cannon 1, and Joseph W. Ferrebee M.D.1

1 From the Department of Surgery, New York University Medical Center, New York, 10016, The Medical College of Virginia, Richmond, Virginia 23219, and the Mary Imogene Bassett Hospital (affiliated with Columbia University), Cooperstown, New York, 13326

The DL-A system of histocompatibility plays an important role in conditioning the survival of cardiac allografts in the unmodified canine host. The mean survival time of six cardiac allografts performed in DL-A-compatible littermate dogs obtained from a closely bred colony of beagles was 53.2 days, while the MST of transplants performed in seven DL-A-incompatible animals was 7.3 days. The MST of cardiac allografts performed in nine DL-A-compatible nonlittermate beagles was 26.3 days, as compared with 6.3 days in six DL-A-incompatible nonlittermate transplants. The results did not appear to be affected by Swisher erythrocyte-group incompatibilities. The MST of 28 cardiac allografts performed in randomly selected mongrel dogs was 10.0 days.

Incompatibilities for DL-A antigens e, f, g, l, and m may constitute major barriers to transplantation, but antigens b, c, d, and k appeared to act as weak histocompatibility antigens.

Under controlled conditions of donor-recipient DL-A compatibility, cardiac allografts may be less immunogenic than renal transplants. Heart transplants performed across major donor-recipient DL-A incompatibilities appeared, however, to be more vulnerable to the events of allograft rejection than renal allografts performed under similar conditions.

The selection of optimally compatible donor-recipient combinations for organ transplantation may be aided materially by genetic studies of the transmission of DL-A antigens to the animals under consideration.

 Submitted on September 2, 1970


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