The Journal of Experimental Medicine
Fluorescence In Vivo Endomicroscopy
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The Journal of Experimental Medicine, Vol 133, 169-186, Copyright © 1971 by The Rockefeller University Press

ARTICLE

CARRIER FUNCTION IN ANTI-HAPTEN ANTIBODY RESPONSES : III. STIMULATION OF ANTIBODY SYNTHESIS AND FACILITATION OF HAPTEN-SPECIFIC SECONDARY ANTIBODY RESPONSES BY GRAFT-VERSUS-HOST REACTIONS



David H. Katz M.D.1, William E. Paul M.D.1, Edmond A. Goidl 1, and Baruj Benacerraf M.D.1

1 From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, and the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02130

The studies reported here demonstrate that immunocompetent lymphoid cells from allogeneic donor guinea pigs stimulate the synthesis of anti-DNP and anti-OVA antibodies by recipients previously primed with DNP-OVA. This allogeneic effect occurs spontaneously in the absence of any further anti-genic challenge. Furthermore, the transfer of allogeneic cells prepares DNP-OVA-primed recipients for a striking secondary anti-DNP response to DNP-BGG; this occurs in equal degree whether or not the cells are derived from BGG-primed donors. We suggest that the allogeneic cells function by virtue of a specific immunologic attack of grafted cells on host cells. This conclusion is made on the basis of the following evidence: (a) The failure of observing the phenomenon with L2C leukemia cells and irradiated strain 2 lymph node and spleen cells which, although capable of initiating a host-versus-graft response, are incapable of mediating graft-versus-host reactions; and (b) the inability of (strain 2 x strain 13) F1 hybrids to mediate the allogeneic effect in strain 13 recipients. The analysis of this phenomenon may offer a key to the delineation of mechanisms involved in the activation of precursors of antibody-forming cells.

Submitted on September 11, 1970


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