The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 133, 39-52, Copyright © 1971 by The Rockefeller University Press

ARTICLE

IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : XLVII. THE I ANTIGEN COMPLEX — PRECURSORS IN THE A, B, H, LEa, AND LEb BLOOD GROUP SYSTEM — HEMAGGLUTINATION-INHIBITION STUDIES



Ten Feizi M.D.1, Elvin A. Kabat Ph.D.1, Giuseppe Vicari M.D.1, Byron Anderson Ph.D.1, and W. Laurence Marsh 1

1 From the Departments of Microbiology, Neurology, and Human Genetics and Development, Columbia University, New York 10032, The Neurological Institute, Presbyterian Hospital, New York 10032, The Rockefeller University, New York 10021, and the New York Blood Center, New York 10021

A partially purified blood group-like substance obtained from milk showed I activity with 2 of 21 anti-I sera. With these antisera, certain human ovarian cyst substances considered to be precursors of the A, B, H, Lea, and Leb substances also showed I activity comparable to the milk material. Strong I activity could be produced by one-stage periodate oxidation and Smith degradation of human ovarian cyst A and B substances, or of hog mucin A + H substance, or by mild acid hydrolysis of human saliva or ovarian cyst blood group B substance. The two sera indicate that I specificity appears at intermediate stages in the biosynthesis of the A, B, H, Lea, and Lea substances. Anti-I sera differ strikingly in their specificities, indicating substantial heterogeneity of the I determinants.

Submitted on August 11, 1970


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