The Journal of Experimental Medicine, Vol 132, 1181-1190,
Copyright © 1970 by The Rockefeller University Press
SURFACE ANTIGENS OF IMMUNOCOMPETENT CELLS
:
I. EFFECT OF 
AND PC.1 ALLOANTISERA ON THE ABILITY OF SPLEEN CELLS TO TRANSFER IMMUNE RESPONSES
T. Takahashi M.D.1,
E. A. Carswell 1, and
G. J. Thorbecke M.D.1
1 From the Division of Immunology, Sloan-Kettering Institute for Cancer Research, New York, 10021, and the Department of Pathology, New York University, School of Medicine, New York 10016
Spleen cell transfer studies were done in BALB/c strain mice in an attempt to define the role of 
-antigen-bearing lymphoid cells in immune responses to SE. Incubation with alloantiserum to -C3H and rabbit C' virtually completely abolished the ability of the cells to transfer both primary and secondary (IgM and IgG) responses to 650 R irradiated recipients. Normal thymus cells partially reconstituted the ability of such treated cells to transfer the primary but not the secondary response. The results are interpreted as showing immunological memory for SE in the -bearing thymus-derived cells.
Incubation of the spleen cells with alloantiserum to the PC.1 antigen present on antibody-forming cells did not significantly affect the ability to transfer either primary or secondary response.
Submitted on July 23, 1970
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