The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 132, 353-367, Copyright © 1970 by The Rockefeller University Press

ARTICLE

ANTIGEN-SPECIFIC SYNERGISM IN THE IMMUNE RESPONSE OF IRRADIATED MICE GIVEN MARROW CELLS AND PERITONEAL CAVITY CELLS OR EXTRACTS

James C. Kennedy M.D.1, Perry E. Treadwell Ph.D.1, and Edwin S. Lennox Ph.D.1

1 From the Salk Institute for Biological Studies, San Diego, California 92112, and the Department of Pathology, Queen's University, Kingston, Ontario

A synergistic immune response to foreign erythrocytes may be induced in heavily irradiated mice injected with a mixture of isologous cells obtained from marrow and from the peritoneal cavity. Under appropriate conditions, homologous or heterologous peritoneal cavity cells, heat-killed cells, or cellfree extracts made from such cells are also effective. The activity of the peritoneal cavity cells or extracts is antigen-specific, in the sense that cells or extracts obtained from animals previously immunized with the test antigen produce much stronger synergistic effects than do cells from animals immunized with some other antigen; however, the peritoneal cavity cells or extracts are not immunogenic when tested in primed animals. The marrow cells, demonstrated to contain precursors of the antibody-forming cells produced during this synergistic immune response, also show a form of antigen-specificity.

Submitted on April 2, 1970


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