The Journal of Experimental Medicine
Keystone Symposia
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The Journal of Experimental Medicine, Vol 132, 300-316, Copyright © 1970 by The Rockefeller University Press

ARTICLE

HOST DEFENSE AGAINST BACTERIAL ENDOTOXEMIA: MECHANISM IN NORMAL ANIMALS

Robert C. Skarnes Ph.D.1

1 From The Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545

The present study defines the early response of normal rabbits to the intravenous injection of a single, sublethal dose of endotoxin. Within the first few hours following endotoxin there occurs in the circulating plasma of recipients a decrease in ionized calcium, a threefold increase in the heat-stable, organo-phosphate-resistant esterase level, and a striking increase in the endotoxin-detoxifying capacity. These results are fully consistent with the thesis that circulating plasma represents a principal site of detoxification and that plasma esterases of the nonspecific, carboxylic type are of major concern in defense against circulating endotoxins.

Submitted on April 2, 1970


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