The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 132, 31-43, Copyright © 1970 by The Rockefeller University Press

ARTICLE

ANTIBODY-MEDIATED SUPPRESSION OF THE IMMUNE RESPONSE IN VITRO : II. A NEW APPROACH TO THE PHENOMENON OF IMMUNOLOGICAL TOLERANCE



Erwin Diener Ph.D.1 and Marc Feldmann M.B.1

1 From The Walter and Eliza Hall Institute of Medical Research, Parkville, 3050, Victoria, Australia

Immunological tolerance to H antigens of Salmonella adelaide may be induced in vitro by the exposure of mouse spleen cells for 6 hr to an immunogenic dose of polymerized flagellin in the presence of low concentrations of specific antibody. Such antibody-mediated tolerance requires an optimal antigen: antibody ratio for its induction. A shift in this ratio in favor of the antibody concentration results in failure of tolerance induction and leads to immune suppression commonly known as antibody-mediated feedback inhibition which is not analogous to immunological tolerance.

Fragment A of flagellin fails to induce immunological tolerance in vitro. Tolerance to polymerized flagellin may however be induced in vitro, provided the spleen cells are exposed to fragment A in the presence of specific antibody for 6 hr. The results are discussed in the light of current theories of the mechanism of tolerance induction.

 Submitted on February 1, 1970


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