The Journal of Experimental Medicine
ThymUS '08
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The Journal of Experimental Medicine, Vol 131, 1200-1210, Copyright © 1970 by The Rockefeller University Press

ARTICLE

PEYER'S PATCHES: IMMUNOLOGIC STUDIES

Claudia Henry Ph.D.1, W. Page Faulk M.D.1, Lotte Kuhn 1, J. M. Yoffey M.D.1, and H. Hugh Fudenberg M.D.1

1 From the Section of Hematology and Immunology, Department of Medicine, and the Laboratory of Radiobiology, University of California, San Francisco Medical Center, San Francisco, California 94122

The immune capabilities of the Peyer's patches have been investigated by the use of an in vitro system.

Despite our failure to stimulate Peyer's patch lymphocytes in vivo it appears that Peyer's patches behave immunologically as peripheral lymphoid tissues.

Cultures prepared from the dissociated Peyer's patches of normal rabbits respond to sheep erythrocytes. The response is comparable to that obtained with spleen cultures from the same animals and is not dependent on the presence of the epithelial cells which line the lumen. Similar thymic cultures do not respond.

Our experiments with cultures prepared from rabbits which have received one or two injections of SRC show that the Peyer's patches contain both IgM and IgG "memory" cells which have migrated from the spleen. The concentration of these cells in the spleen remains several hundredfold higher.

 Submitted on December 22, 1969


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