The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 131, 843-850, Copyright © 1970 by The Rockefeller University Press

ARTICLE

IN VITRO INTERACTION OF MOUSE HEPATITIS VIRUS AND MACROPHAGES FROM GENETICALLY RESISTANT MICE : I. ADSORPTION OF VIRUS AND GROWTH CURVES



Ilan Shif Sc.D.1 and Frederik B. Bang M.D.1

1 From the Department of Pathobiology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205

Peritoneal macrophages from genetically resistant C3H mice and genetically susceptible Princeton (PRI) mice adsorbed the MHV (PRI) strain of mouse hepatitis virus equally well. The difference between the permissive cells and the nonpermissive ones seems to reside in the ability of the former to "eclipse" the virus and, subsequently, support virus replication. C3H cells exposed to low multiplicities of the virus remained intact with no demonstrable viral replication. Virus, taken up by the resistant cells, was protected from heat and underwent slow inactivation while few or no virus particles were released into the medium.

Submitted on November 19, 1969


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