The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 131, 343-354, Copyright © 1970 by The Rockefeller University Press

ARTICLE

ALLOTYPE EXCLUSION IN UNIFORM RABBIT ANTIBODY TO STREPTOCOCCAL CARBOHYDRATE

Thomas J. Kindt Ph.D.1, Charles W. Todd Ph.D.1, Klaus Eichmann M.D.1, and Richard M. Krause M.D.1

1 From the Biology Department, City of Hope Medical Center, Duarte, California 91010, and The Rockefeller University, New York 10021

Rabbit antibodies to streptococcal polysaccharide are described which show selectivity of expression of the allotypic specificities on both the heavy (H) and light (L) chains. One of these antibodies binds weakly to Sephadex. A purification method based on this binding has yielded antibody completely lacking any group a allotypic marker on its H chains.

Submitted on September 16, 1969


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