The Journal of Experimental Medicine
ThymUS '08
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The Journal of Experimental Medicine, Vol 131, 331-341, Copyright © 1970 by The Rockefeller University Press

ARTICLE

CYTOGENETIC STUDIES OF LEUKEMIA INDUCED BY 6,8,12- AND 7,8,12-TRIMETHYLBENZ(A)ANTHRACENE

Taketoshi Sugiyama M.D.1 and Filomena P. Brillantes 1

1 From the Ben May Laboratory for Cancer Research, The University of Chicago, Chicago, Illinois 60637

Cytogenetic studies on 64 rat leukemias induced with 7,8,12- and 6,8,12-trimethylbenz(a)anthracene were performed. Highly distinctive changes were found repeatedly in one special pair of chromosomes. 10 leukemias (15.6%) showed the presence of stemline(s) with trisomy of the largest telocentric chromosome (C-1 trisomy). Another chromosome abnormality, elongation of one of the pairs of the same chromosome (long C-1), was found in 5 leukemias (7.8%) as the predominant stemline and in 7 other cases as a small cell population. This chromosome abnormality, despite slight differences in their elongation rate, was defined as a new specific chromosome abnormality. Other chromosome abnormalities not related with C-1 chromosome were found in 8 cases (12.5%). The remaining 41 leukemias (64.1%) had the predominant stemline with normal karyotype. From this study it appears that three structurally different hydrocarbon carcinogens, 7,12-dimethylbenz(a)anthracene and 7,8,12- and 6,8,12-trimethylbenz(a)anthracene act on blood-forming cells by a common specific mechanism.

Submitted on September 12, 1969


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