The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 131, 321-330, Copyright © 1970 by The Rockefeller University Press

ARTICLE

HUNDRED DAY LEUKEMIA: PREFERENTIAL INDUCTION IN RAT BY PULSE-DOSES OF 7,8,12-TRIMETHYLBENZ(A)ANTHRACENE

Charles Huggins M.D.1, Lorraine Grand 1, and Hisao Oka M.D.1

1 From The Ben May Laboratory for Cancer Research, The University of Chicago, Chicago, Illinois 60637

A series of pulse-doses of 7, 8, 12-trimethylbenz(a)anthracene-induced leukemia rapidly and consistently in very high yield in rats of Long-Evans (L-E) strain. The predominant type was a diffuse hepatic leukemia of erythroblastic stem cells.

Progressive hypothermia and a decline in pituitary function are newly recognized signs of advanced leukemia in rat.

 Submitted on September 12, 1969


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