The Journal of Experimental Medicine
Randox clinical diagnostic solutions
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Henson, P. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Henson, P. M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 131, 287-306, Copyright © 1970 by The Rockefeller University Press

ARTICLE

RELEASE OF VASOACTIVE AMINES FROM RABBIT PLATELETS INDUCED BY SENSITIZED MONONUCLEAR LEUKOCYTES AND ANTIGEN

P. M. Henson Ph.D.1

1 From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

The immunological release of vasoactive amines from rabbit platelets by a mechanism requiring blood leukocytes has been described. The reaction involved leukocytes from an immunized rabbit, antigen, and platelets and did not require the complement system. The leukocytes appeared to be mononuclear, had the ability to adhere to glass, and were found in greater numbers in the blood than in spleen, lymph nodes, thoracic duct lymph, bone marrow, and peritoneal cavity washings.

Part or all of the effect on the platelets appeared to result from active release of a soluble factor from the leukocytes, which induced vasoactive amine release from the platelets. The platelets were not lysed during this reaction and the release of vasoactive amines required the active participation of metabolic pathways in the platelet.

 Submitted on September 8, 1969


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS