LACTOFERRIN, AN IRON-BINBING PROTEIN NI NEUTROPHILIC LEUKOCYTES

doi:10.1084/jem.130.3.643

This Article

Full Text (PDF)

Alert me when this article is cited

Citation Map

Services

Email this article

Similar articles in this journal

Similar articles in PubMed

Alert me to new content in the JEM

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via CrossRef

Citing Articles via Google Scholar

Google Scholar

Articles by Masson, P. L.

Articles by Schonne, E.

Search for Related Content

PubMed

PubMed Citation

Articles by Masson, P. L.

Articles by Schonne, E.

Pubmed/NCBI databases

Hazardous Substances DB
Compound via MeSH
Substance via MeSH
IRON

Social Bookmarking

What's this?

ARTICLE

LACTOFERRIN, AN IRON-BINBING PROTEIN NI NEUTROPHILIC LEUKOCYTES

P. L. Masson M.D.¹, J. F. Heremans M.D.¹, and E. Schonne Ph.D.¹

¹ From the Department of Experimental Medicine, Cliniques Universitaires Saint-Pierre, Brusselsestraat, 69, Louvain, Belgium

Lactoferrin, an iron-binding protein previously shown to occurin many external secretions, is identified as one of the majorproteins present in human and guinea pig neutrophilic polymorphonuclearleukocytes.

The identification of this protein in leukocyteextracts was based upon a comparison of its electrophoretic,antigenic, and iron-combining properties with the correspondingproperties of the same protein isolated from human and guineapig milk. Immunochemical quantitations showed that lactoferrinoccurs in human neutrophilic leukocytes at the concentrationof 3 µg per 10⁶ cells. Tissue cultures from guinea pigbone marrow and spleen actively synthesized the protein, asshown both by net production of lactoferrin and incorporationof labeled amino acids into the protein. Immunohistochemicaldata indicate that lactoferrin first appears in myeloid cellsat the stage of the promyelocyte.

Submitted on April 7, 1969

Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Venkatesh, M. P., Rong, L. (2008). Human recombinant lactoferrin acts synergistically with antimicrobials commonly used in neonatal practice against coagulase-negative staphylococci and Candida albicans causing neonatal sepsis. J Med Microbiol 57: 1113-1121 [Abstract] [Full Text]
de la Rosa, G., Yang, D., Tewary, P., Varadhachary, A., Oppenheim, J. J. (2008). Lactoferrin Acts as an Alarmin to Promote the Recruitment and Activation of APCs and Antigen-Specific Immune Responses. J. Immunol. 180: 6868-6876 [Abstract] [Full Text]
Oh, S.-M., Lee, S.-H., Lee, B.-J., Pyo, C.-W., Yoo, N.-K., Lee, S. Y., Kim, J., Choi, S.-Y. (2007). A Distinct Role of Neutrophil Lactoferrin in RelA/p65 Phosphorylation on Ser536 by Recruiting TNF Receptor-Associated Factors to I{kappa}B Kinase Signaling Complex. J. Immunol. 179: 5686-5692 [Abstract] [Full Text]
Wolf, J. S., Li, G., Varadhachary, A., Petrak, K., Schneyer, M., Li, D., Ongkasuwan, J., Zhang, X., Taylor, R. J., Strome, S. E., O'Malley, B. W. Jr. (2007). Oral Lactoferrin Results in T Cell-Dependent Tumor Inhibition of Head and Neck Squamous Cell Carcinoma In vivo. Clin. Cancer Res. 13: 1601-1610 [Abstract] [Full Text]
Logsdon, L. K., Mecsas, J. (2006). The Proinflammatory Response Induced by Wild-Type Yersinia pseudotuberculosis Infection Inhibits Survival of yop Mutants in the Gastrointestinal Tract and Peyer's Patches. Infect. Immun. 74: 1516-1527 [Abstract] [Full Text]
Leon-Sicairos, N., Reyes-Lopez, M., Canizalez-Roman, A., Bermudez-Cruz, R. M., Serrano-Luna, J., Arroyo, R., de la Garza, M. (2005). Human hololactoferrin: endocytosis and use as an iron source by the parasite Entamoeba histolytica. Microbiology 151: 3859-3871 [Abstract] [Full Text]
Wang, Y., Tu, Y., Han, F., Xu, Z., Wang, J. (2005). Developmental Gene Expression of Lactoferrin and Effect of Dietary Iron on Gene Regulation of Lactoferrin in Mouse Mammary Gland. J DAIRY SCI 88: 2065-2071 [Abstract] [Full Text]
Fujita, K.-i., Matsuda, E., Sekine, K., Iigo, M., Tsuda, H. (2004). Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats. Carcinogenesis 25: 1961-1966 [Abstract] [Full Text]
Velliyagounder, K., Kaplan, J. B., Furgang, D., Legarda, D., Diamond, G., Parkin, R. E., Fine, D. H. (2003). One of Two Human Lactoferrin Variants Exhibits Increased Antibacterial and Transcriptional Activation Activities and Is Associated with Localized Juvenile Periodontitis. Infect. Immun. 71: 6141-6147 [Abstract] [Full Text]
Majerle, A., Kidric, J., Jerala, R. (2003). Enhancement of antibacterial and lipopolysaccharide binding activities of a human lactoferrin peptide fragment by the addition of acyl chain. J Antimicrob Chemother 51: 1159-1165 [Abstract] [Full Text]
Ward, P. P., Mendoza-Meneses, M., Cunningham, G. A., Conneely, O. M. (2003). Iron Status in Mice Carrying a Targeted Disruption of Lactoferrin. Mol. Cell. Biol. 23: 178-185 [Abstract] [Full Text]
Elass, E., Masson, M., Mazurier, J., Legrand, D. (2002). Lactoferrin Inhibits the Lipopolysaccharide-Induced Expression and Proteoglycan-Binding Ability of Interleukin-8 in Human Endothelial Cells. Infect. Immun. 70: 1860-1866 [Abstract] [Full Text]
Teng, C. T., Gladwell, W., Beard, C., Walmer, D., Teng, C. S., Brenner, R. (2002). Lactoferrin gene expression is estrogen responsive in human and rhesus monkey endometrium. Mol Hum Reprod 8: 58-67 [Abstract] [Full Text]
Conneely, O. M. (2001). Antiinflammatory Activities of Lactoferrin. J. Am. Coll. Nutr. 20: 389S-395 [Abstract] [Full Text]
Samaranayake, Y. H., Samaranayake, L. P., Pow, E. H. N., Beena, V. T., Yeung, K. W. S. (2001). Antifungal Effects of Lysozyme and Lactoferrin against Genetically Similar, Sequential Candida albicans Isolates from a Human Immunodeficiency Virus-Infected Southern Chinese Cohort. J. Clin. Microbiol. 39: 3296-3302 [Abstract] [Full Text]
Hakansson, A., Roche, H., Mirza, S., McDaniel, L. S., Brooks-Walter, A., Briles, D. E. (2001). Characterization of Binding of Human Lactoferrin to Pneumococcal Surface Protein A. Infect. Immun. 69: 3372-3381 [Abstract] [Full Text]
Baveye, S., Elass, E., Fernig, D. G., Blanquart, C., Mazurier, J., Legrand, D. (2000). Human Lactoferrin Interacts with Soluble CD14 and Inhibits Expression of Endothelial Adhesion Molecules, E-Selectin and ICAM-1, Induced by the CD14-Lipopolysaccharide Complex. Infect. Immun. 68: 6519-6525 [Abstract] [Full Text]
Caccavo, D., Afeltra, A., Pece, S., Giuliani, G., Freudenberg, M., Galanos, C., Jirillo, E. (1999). Lactoferrin-Lipid A-Lipopolysaccharide Interaction: Inhibition by Anti-Human Lactoferrin Monoclonal Antibody AGM 10.14. Infect. Immun. 67: 4668-4672 [Abstract] [Full Text]
Sallmann, F. R., Baveye-Descamps, S., Pattus, F., Salmon, V., Branza, N., Spik, G., Legrand, D. (1999). Porins OmpC and PhoE of Escherichia coli as Specific Cell-surface Targets of Human Lactoferrin. BINDING CHARACTERISTICS AND BIOLOGICAL EFFECTS. J. Biol. Chem. 274: 16107-16114 [Abstract] [Full Text]
Ward, P. P., Mendoza-Meneses, M., Mulac-Jericevic, B., Cunningham, G. A., Saucedo-Cardenas, O., Teng, C. T., Conneely, O. M. (1999). Restricted Spatiotemporal Expression of Lactoferrin during Murine Embryonic Development. Endocrinology 140: 1852-1860 [Abstract] [Full Text]
Fillebeen, C., Descamps, L., Dehouck, M.-P., Fenart, L., Benaissa, M., Spik, G., Cecchelli, R., Pierce, A. (1999). Receptor-mediated Transcytosis of Lactoferrin through the Blood-Brain Barrier. J. Biol. Chem. 274: 7011-7017 [Abstract] [Full Text]
Bernstein, L. R. (1998). Mechanisms of Therapeutic Activity for Gallium. Pharmacol. Rev. 50: 665-682 [Abstract] [Full Text]
Chapple, D. S., Mason, D. J., Joannou, C. L., Odell, E. W., Gant, V., Evans, R. W. (1998). Structure-Function Relationship of Antibacterial Synthetic Peptides Homologous to a Helical Surface Region on Human Lactoferrin against Escherichia coli Serotype O111. Infect. Immun. 66: 2434-2440 [Abstract] [Full Text]
Guillén, C, McInnes, I B, Kruger, H, Brock, J H (1998). Iron, lactoferrin and iron regulatory protein activity in the synovium; relative importance of iron loading and the inflammatory response. Ann Rheum Dis 57: 309-314 [Abstract] [Full Text]
Elass-Rochard, E., Legrand, D., Salmon, V., Roseanu, A., Trif, M., Tobias, P. S., Mazurier, J., Spik, G. (1998). Lactoferrin Inhibits the Endotoxin Interaction with CD14 by Competition with the Lipopolysaccharide-Binding Protein. Infect. Immun. 66: 486-491 [Abstract] [Full Text]
Ward, P. P., Zhou, X., Conneely, O. M. (1996). Cooperative Interactions between the Amino- and Carboxyl-terminal Lobes Contribute to the Unique Iron-binding Stability of Lactoferrin. J. Biol. Chem. 271: 12790-12794 [Abstract] [Full Text]