The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 130, 493-504, Copyright © 1969 by The Rockefeller University Press

ARTICLE

THE NATURE OF THE ANTIGENIC DETERMINANT IN A GENETIC CONTROL OF THE ANTIBODY RESPONSE

Edna Mozes Ph.D.1, Hugh O. McDevitt M.D.1, Jean-Claude Jaton Ph.D.1, and Michael Sela Ph.D.1

1 From the Division of Immunology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 and the Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel

The response of inbred mouse strains to two polypeptides derived from multichain polyprolines, (T,G)-Pro--L and (Phe,G)-Pro--L, is different from the response of the same mouse strains to a similar series of polymers built on multi-poly-D,L-alanyl--poly-L-lysine, although the same short sequences of amino acids are attached to the side chains of the polypeptides in the two series. These results indicate that a portion of the side chain (e.g. polyalanine or polyproline) participates in the antigenic determinant. This was confirmed by studying the response of different mouse strains to two kinds of polypeptides: (T,G)-Pro-A--L 717 and 718 and (T,G)-A-Pro--L 719 and 721.

Antibody assay of antisera to (Phe,G)-Pro--L with the cross-reacting antigens (T,G)-Pro--L and (Phe,G)-A-L indicates that different inbred mouse strains make antibodies specific for different parts of the same polypeptide. Thus, antibody from DBA/1 mice reacts almost exclusively with the (Phe,G) sequence, while SJL antisera bind only (T,G)-Pro--L and fail to bind (Phe,G)-A-L.

The immune responses to the same amino acids on two different polypeptides (i.e. A--L and Pro--L) appear to be under separate genetic control.

 Submitted on April 29, 1969


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