The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 128, 1385-1400, Copyright © 1968 by The Rockefeller University Press

ARTICLE

CAPSULATION OF PNEUMOCOCCUS WITH SOLUBLE C-LIKE (Cs) POLYSACCHARIDE : I. BIOLOGICAL AND GENETIC PROPERTIES OF Cs PNEUMOCOCCAL STRAINS



Donald L. Bornstein M.D.1, Gerald Schiffman Ph.D.1, Harriet P. Bernheimer Ph.D.1, and Robert Austrian M.D.1

1 From the John Herr Musser Department of Research Medicine, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, and the Department of Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York 11203

Capsulated mutants of pneumococcus producing a capsule of soluble polysaccharide related immunologically to the C or cell wall polysaccharide of pneumococcus have been isolated from several noncapsulated variants of this organism. The capsular material of these strains reacts with antisera both to homologous strains and to noncapsulated strains of pneumococcus and with human C-reactive protein. C-reactive protein has been shown to give a positive capsular precipitin or Quellung reaction with Cs pneumococcal variants and to agglutinate them.

The genetic locus which determines the production of Cs polysaccharide is situated in a region of the pneumococcal chromosome distinct from that controlling normal capsular polysaccharide synthesis. Binary and ternary capsulated pneumococci, one of the capsular components of which is Cs polysaccharide, have been isolated following DNA-mediated transformation.

 Submitted on August 20, 1968


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