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The Journal of Experimental Medicine, Vol 128, 1353-1362, Copyright © 1968 by The Rockefeller University Press

ARTICLE

CELLULAR DIFFERENTIATION AND THE AGING PROCESS IN CARTILAGINOUS TISSUES : MUCOPOLYSACCHARIDE SYNTHESIS IN CELL CULTURES OF CHONDROCYTES



Herbert J. Shulman M.D.1 and Karl Meyer M.D.1

1 From The Department of Medicine, Columbia University College of Physicians and Surgeons, the Edward Daniels Faulkner Arthritis Clinic of the Presbyterian Hospital, New York 10032, and the Belfer Graduate School of Science, Yeshiva University, New York, New York 10033

Primary cell cultures of differentiated chondrocytes were shown to produce chondroitin-4-sulfate as the predominant mucopolysaccharide, with suggestive evidence for the synthesis of keratan sulfate and possibly chondroitin-6-sulfate.

Chicken embryonic cartilage was shown to be composed mainly of chondroitin-4-sulfate, with a small amount of chondroitin-6-sulfate, but essentially no keratan sulfate.

These findings were compared to the data of others, and a hypothesis explaining the aging process in cartilage in terms of cellular differentiation was presented.

 Submitted on August 2, 1968


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